Why is this medication prescribed?
Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease.
Drug class and mechanism:
Rivastigmine is in a class of drugs called cholinesterase inhibitors that also includes tacrine (Cognex®), donezepil (Aricept®), and galantamine (Reminyl®).
Cholinesterase inhibitors block the action of acetylcholinesterase, the enzyme responsible for the destruction of acetylcholine. Acetylcholine is one of several neurotransmitters in the brain, chemicals that nerve cells use to communicate with one another. Reduced levels of acetylcholine in the brain are believed to be responsible for some of the symptoms of Alzheimer's disease. By blocking the enzyme that destroys acetylcholine, rivastigmine increases the concentration of acetylcholine in the brain, and this increase is believed to be responsible for the improvement in thinking seen with rivastigmine.
For most patients who take rivastigmine there will not be a dramatic improvement, but the progression of symptoms may be slowed. After 6 months of treatment with rivastigmine, 25-30% of patients scored better on tests of memory, understanding, and activities of daily living as compared with only 10-20% of patients receiving placebo (a dummy or sugar pill).
Dosage and using this medicine
What special precautions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?